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Wednesday, April 21, 2010
Sunday, April 18, 2010
Hope for Duchenne
Professor Tremblay's team partnered with Cellectis, a French firm specializing in genome engineering, in order to design enzymes-called meganucleases-with the ability to correct the dystrophin gene. During in vitro testing, the researchers inserted genes coding for a variety of meganucleases into human muscle cells.
They repeated the experiment in vivo with mice carrying the mutation that causes the illness. Both series of testing showed that the meganucleases can lead to a restoration of the normal nucleotide sequences of the dystrophin gene and its expression in muscle cells.
Wednesday, April 14, 2010
Friday, April 9, 2010
Hope for Duchenne
Can muscle stem cells from muscular dystrophy sufferers be corrected in a sustained fashion, and ultimately "cured"? Using a gene therapy technique, "exon skipping"1, a Franco-Italian research team coordinated by CNRS researcher Luis Garcia2 and Yvan Torrente3 has achieved this. These researchers have, for the first time, restored the functionality of human dystrophin, the protein that is missing in a setting of Duchenne muscular dystrophy, which is the most common of the neuromuscular diseases. They then transplanted these "corrected" human cells into mouse models of this disease in order to test their efficacy, and the muscle performance of these animals was seen to be improved. Published on December 13, 2007 in the journal Cell
Stem Cell, this work received partial support from the Généthon, the laboratory set up and funded by the AFM thanks to donations to the Téléthon. It constitutes a step forward in autologous cell therapy using the patient's own "rehabilitated" cells.
SOURCE: http://www.institut-myologie.org/anglais/e_upload/pdf/cp_myopathie-anglais.pdf
ON April 9, 2010 at 20:08 hours
Stem Cell, this work received partial support from the Généthon, the laboratory set up and funded by the AFM thanks to donations to the Téléthon. It constitutes a step forward in autologous cell therapy using the patient's own "rehabilitated" cells.
SOURCE: http://www.institut-myologie.org/anglais/e_upload/pdf/cp_myopathie-anglais.pdf
ON April 9, 2010 at 20:08 hours
Thursday, April 8, 2010
Tuesday, April 6, 2010
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